Historically creatine supplementation has been reserved for athletes. For many decades professional and amateur athletes have supplemented with creatine to improve strength gains and augment performance and recovery. New research illustrates the other beneficial properties of creatine, suggesting supplementation may be helpful in chronic fatigue syndrome and fibromyalgia.
Creatine is an excellent energy source for the cell’s powerhouse, the mitochondria. Its effects on the mitochondria are two-fold: protective and enhancing. It acts as an antioxidant, quenching free radicals and lactic acid. Once ingested, creatine is converted to phosphocreatine—a substrate of cellular energy (ATP) production (1). Finally, it helps stabilize the mitochondrial membrane by increasing cardiolipin—a protein that acts like scaffolding for the delicate mitochondria (2).
Kre-Alkalyn is a patented, next-generation alkaline form of creatine. Its key features differ from traditional creatine powders due to the fact that it is more alkaline, which enables enhanced support for lactic acid and metabolic acid buffering. Kre-Alkalyn also enables a high concentration of cellular creatine to be absorbed at a lower effective dose without the need for a “loading phase” of high doses. Also, Kre-Alkalyn does not cause water retention and is safe to take daily.
Creatine & Fibromyalgia
Kre-Alkalyn may lessen muscle soreness in fibromyalgia due to lactic acid build-up. A 16-week double-blind, randomized control study in fibromyalgia patients showed creatine supplementation increased intramuscular phosphocreatine content by 80% (more ATP available) and improved lower and upper body muscle function, with some additional effects on general symptoms (3).
Creatine & the Methylation Cycle
The body’s production of creatine represents a large proportion of methylation demands (1). Methylation cycle dysfunction is a proposed hypothesis of CFS pathophysiology. Supplemental creatine acts as a methyl donor, bolstering DNA methylation in individuals with methylation defects (e.g. MTHFR).
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* Did you know Dr. Craig donates a portion of all supplement sales to CFS & Fibromyalgia research & advocacy groups?
1 Wallimann T1, Tokarska-Schlattner M, Schlattner U. (2011) The creatine kinase system and pleiotropic effects of creatine. Amino Acids. 40(5):1271-96. Epub 2011 Mar 30. http://www.ncbi.nlm.nih.gov/pubmed/21448658
2 Tokarska-Schlattner M (2012) Phosphocreatine interacts with phospholipids, affects membrane properties and exerts membrane-protective effects. PLoS One. 7(8):e43178. Epub 2012 Aug 17. http://www.ncbi.nlm.nih.gov/pubmed/22912820
3 Alves CR, et al. (2013) Creatine supplementation in fibromyalgia: a randomized, double-blind, placebo-controlled trial. Arthritis Care Res (Hoboken). 65(9):1449-59. http://www.ncbi.nlm.nih.gov/pubmed/23554283