Product Spotlight: Active B-Complex

Since we cannot synthesize folates, they must be obtained from the diet. The folates found in foods are predominantly in the dihydrofolate (DHF) or tetrahydrofolate (THF) form. These forms are not considered biologically active and must be converted to active folate; 5-methyltetrahydrofolate (5-MTHF). In many individuals this conversion may be inefficient due to MTHFR snps or compromised intestinal integrity—both of which are common to CFS and fibromyalgia. If this conversion does not occur, unmetabolized folic acid (UMFA) may build up in the system potentially disrupting DNA and RNA synthesis. (1)

Image Courtesy of The Institute for Functional Medicine

Image Courtesy of The Institute for Functional Medicine

Active B-Complex from Integrative Therapeutics is an inexpensive, hypoallergenic B-complex formula featuring the active forms of vitamins B1, B2, B6, and B12. It also contains Quatrefolic, the stabilized salt of 5-methyltetrahydrofolate (5-MTFH), a reduced and active form of folic acid. 5-methyltetrahydrofolate (5-MTHF) is directly usable by the human body as a methyl donor and as such, supports healthy methylation and homocysteine levels. (2)

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Quatrefolic is (6S)-5-methylfolate, a stable and highly-soluble form of 5-MTHF. Folic acid (FA), in contrast, is a synthetic, oxidized form of the vitamin that has been conventionally used for supplementation and food fortification. Quatrefolic is estimated to be 100 times more soluble than the commonly used calcium salt of 5-MTHF. (3) 

You can find Active B-Complex in the dispensary

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* Did you know Dr. Craig donates a portion of all supplement sales to CFS & Fibromyalgia research and advocacy groups?


1  Kelly P, McPartlin J, Goggin M, Weir DG, Scott JM. (1997) Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements. Am J Clin Nutr. 65:1790–5.

2  Fohr IP, Prinz-Langenohl R, Brönstrup A, et al. (2002) 5, 10-Methylenetetrahydrofolate reductase genotype determines the plasma homocysteine-lowering effect of supplementation with 5-methyltetrahydrofolate or folic acid in healthy young women. Am J Clin Nutr. 75:275–82.

3  Pentieva K, McNulty H, Reichert R, et al. (2004) The short-term bioavailabilities of [6S]-5-methyltetrahydrofolate and folic acid are equivalent in men. J Nutr. 134(3):580–5.