Master Antioxidant: Glutathione

Glutathione, our bodies’ most powerful antioxidant, is frequently used in CFS & fibromyalgia treatment. Because it is an unstable molecule, it is best given intravenously. New research indicates that needles are no longer necessary and the oral acetylated form is equivalent.

Low tissue glutathione has been observed in a number of chronic conditions including CFS and fibromyalgia. Studies have shown improvement in symptoms with restoration of normal glutathione stores. Supplemental glutathione comes in many forms: inhaled, topical creams, intramuscular injection, or intravenous. Oral supplementation is seen as inefficient and has thus far been ineffective at raising tissue stores.

A new form of glutathione, the acetylated form, provides optimum absorption and bioavailability with the convenience of oral administration. S-Acetyl Glutathione (S-A-GSH) from Designs for Health is well-suited for oral ingestion, because the acetyl group protects glutathione from breaking down in the gastrointestinal tract. Once absorbed and inside the cells, the acetyl group is removed leaving the glutathione molecule intact. Not only has it been shown to remain stable in the gastrointestinal tract, but it also has a longer plasma half-life with improved ability to enter cells and raise intracellular glutathione levels more efficiently.

A recent pilot study following 6 patients used markers of oxidative stress to evaluate GSH action from two dose forms: IV glutathione and oral acetyl-glutathione over one week at a dose of 1400 mg. The researchers concluded that oral S-A-GSH compares favorably to an equivalent dose of IV administered glutathione. (1)


  • Reduces free radical-induced oxidative stress

  • Helps optimize glutathione-dependent hepatic detoxification pathways, including the enhancement of heavy metal clearance

  • Supports immune function

  • Anti-viral properties


You can find various formulations of high-potency Glutathione in the FullScript Store >>        



1 Ash, M. 01 Jan 2011. Oral Glutathione Equivalent to IV Therapy. Clinical Education. Retrieved from Accessed 26 April 14.